Cellular oncomiR orthologue in EBV oncogenesis.
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| Abstract |    :  
                  MicroRNAs are small non-coding RNAs that regulate gene expression at multiple levels. The discovery of virally encoded miRNAs attracted immense attention towards their role in viral replication and pathogenesis. Kaposi's-sarcoma-associated herpes virus encodes miRNA that functions as an orthologue of human cellular miRNA, i.e., hsa-miR-155. Keeping the same view we extended the miRNA-homology search between the miRNAs of humans and Epstein-Barr virus. The In silico analyses shows that EBV encoded miR-BART-5 has a significant 'seed' sequence homology to hsa-miR-18 of humans. Further, the mRNA transcripts of the human genes involved in cellular growth could potentially be targeted by both viral as well as human miRNAs. The known etiological role of hsa-miR-18 as an oncomiR suggests that miR-BART-5 may function as viral oncomiR as observed in EBV-positive gastric carcinoma patients.  | 
        
| Year of Publication |    :  
                  2011 
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| Journal |    :  
                  Computers in biology and medicine 
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| Volume |    :  
                  41 
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| Issue |    :  
                  10 
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| Number of Pages |    :  
                  891-8 
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| ISSN Number |    :  
                  0010-4825 
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| URL |    :  
                  https://linkinghub.elsevier.com/retrieve/pii/S0010-4825(11)00155-7 
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| DOI |    :  
                  10.1016/j.compbiomed.2011.07.007 
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| Short Title |    :  
                  Comput Biol Med 
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