Deletion of the TNFAIP3/A20 gene detected by FICTION analysis in classical Hodgkin lymphoma.
| Author | |
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| Abstract | :
The TNFAIP3 gene, which encodes a ubiquitin-modifying enzyme (A20) involved in the negative regulation of NF-κB signaling, is frequently inactivated by gene deletions/mutations in a variety of B-cell malignancies. However, the detection of this in primary Hodgkin lymphoma (HL) specimens is hampered by the scarcity of Hodgkin Reed-Sternberg (HR-S) cells even after enrichment by micro-dissection. |
| Year of Publication | :
2012
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| Journal | :
BMC cancer
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| Volume | :
12
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| Number of Pages | :
457
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| Date Published | :
2012
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| URL | :
https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-12-457
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| DOI | :
10.1186/1471-2407-12-457
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| Short Title | :
BMC Cancer
|
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