Ipatasertib plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (LOTUS): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.
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| Abstract | :
The oral AKT inhibitor ipatasertib is being investigated in cancers with a high prevalence of PI3K/AKT pathway activation, including triple-negative breast cancer. The LOTUS trial investigated the addition of ipatasertib to paclitaxel as first-line therapy for triple-negative breast cancer. |
| Year of Publication | :
2017
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| Journal | :
The Lancet. Oncology
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| Volume | :
18
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| Issue | :
10
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| Number of Pages | :
1360-1372
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| ISSN Number | :
1470-2045
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| URL | :
https://linkinghub.elsevier.com/retrieve/pii/S1470-2045(17)30450-3
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| DOI | :
10.1016/S1470-2045(17)30450-3
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| Short Title | :
Lancet Oncol
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